Saturday's incident follows a bombing this week that targeted police outside a major Sufi shrine in Lahore, in the north of Pakistan, that killed at least 10 people and wounded more than 20, officials said.
He said the "majority" of guests had been evacuated and security forces were engaging the militants.
The group, which is fighting for independence for Balochistan province where the hotel is located, said afterwards: "Our fighters have carried out this attack on Chinese and other foreign investors who were staying in PC hotel".
According to ARY News correspondent Mustafa Khan Tareen, the militants stormed the Pearl Continental Hotel Gwadar. He also said that "95 per cent of the hotel has been evacuated". He said that security personnel were now battling the terrorists.
On April 18, unidentified gunmen donning uniforms of paramilitary soldiers massacred at least 14 passengers, including Pakistan Navy personnel, after forcing them to disembark from buses on a highway in Balochistan. He said the details would be shared with the media once the operation is over.
Following the attack, Frontier Corps personnel and policemen have cordoned off the area.
The Gwadar port region is the focal point of the multi-billion-dollar China-Pakistan Economic Corridor (CPEC) project, which is part of China's mammoth Belt and Road infrastructure project.
No foreigners were present when the attack took place, he said.
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