McCollum had 24 points while Lillard had 30, as the Blazers' backcourt continued to be the difference for the team.
It was the first post-season meeting between the teams since the Thunder moved from Seattle to Oklahoma City.
The Blazers have endured a miserable record in the playoffs in recent years, suffering back-to-back first round sweeps in 2017 and 2018 against Golden State and New Orleans. However he was just 1 of 6 from the floor in the opening quarter.
George was one of the Thunder's best three-point shooters this season at 39% from long range.
Kanter was definitely key to Portland's game one victory, and he could very well be a huge part of their playoff run moving forward.
George missed the Thunder' regular-season finale Wednesday at Milwaukee because of the nagging injury, which also kept him out of games on February 28, March 2 and March 3.
Portland jumped out to a 26-15 lead early on McCollum's third 3-pointer. But Kanter, signed just before the All-Star break after being waived by the New York Knick, has proven ad admirable fill-in.
Drummond threw a kiss to the Fiserv Forum crowd as he headed to the showers but it might as well be the kiss of death for the Pistons against the NBA's top team (60 wins) in the regular season. Portland outscored OKC 22-21 in the quarter to take a 76-69 lead into the fourth. Previous year as a No. 3 seed Portland got swept by the New Orleans Pelicans.
The Blazers will not have center Jusuk Nurkic, who suffered a broken leg on a gruesome play in late March and missed the last nine games of the season and will be out for the entire playoffs.
"He gave us a lot of toughness inside", Stotts said. I thought his conditioning was really good.
Game 2 is on Tuesday night in Portland - 9:30 PM CST on TNT and Fox Sports Oklahoma.
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