Penaud and France had no answer to one of the world's best finishers.
England's 36-point margin of victory was only just shy of their largest against Les Bleus - a 37-0 win in France's first match at Twickenham back in 1911.
It was a performance symptomatic of a wider problem in French rugby as the crisis deepens following another Six Nations defeat.
Jess Breach scored another two tries as England women's winning start to their Six Nations campaign continued.
After Sarah McKenna was held up over the line, a break down the wing from Kelly Smith was quickly recycled for Poppy Cleall to hit a short line and power over.
France's decision to put two centers on the wings, and a wing at fullback, was ruthlessly exposed as three of England's four tries in the first half came from expertly weighted kicks in behind the defense, where no blue jerseys were anywhere near. We're playing the greatest Welsh side ever; we're going to have to be at our absolute best.
France head coach Jacques Brunel said: "Obviously I'm very, very disappointed".
The Welshman judged that winger Chris Ashton was taken out off the ball, preventing him from scoring a certain try, and after a double checking with his TMO - awarded a penalty try.
But England had a bonus point try on the stroke of half-time.
England ensured the showdown with Wales in two weeks in Cardiff will be extra spicy by crushing France 44-8 at Twickenham on Sunday. It was a tactic that England used heavily against France as they exploited the backs' inability to deal with facing their own touchline.
Guirado was then penalized for not rolling away in a ruck and Owen Farrell kicked England 8-0 ahead in a shower. England bashed at the defense and Farrell passed out left to May, who stepped opposite Damian Penaud and was over.
"We were really under pressure from the English side, especially from their kicking game and we were not able to overcome that".
England had all but wrapped up the match by half-time, leading 30-8 and having already claimed a bonus point after May's hat-trick and one from Henry Slade, leaving France with little to play for in a second half in which they failed to register a single point.
The last 25 minutes went scoreless, with Jones saying he was pleased England didn't relax in the second half.
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