Replacements: Sean Cronin, Dave Kilcoyne, Andrew Porter, Ultan Dillane, Josh van der Flier, John Cooney, Joey Carbery, Jordan Larmour.
Henshaw was expected to return to the more familiar role of centre, allowing Rob Kearney to return to fullback but his absence hands Chris Farrell an opportunity in the midfield while Jack Conan and Quinn Roux replace the injured men in the pack.
Ireland lost their opening fixture against England in Dublin, and will face a Scotland side who won last week at Murrayfield in a 33-20 bonus point win over Italy.
"I'd like to see how they'd describe our Plan A to be honest", said head coach Schmidt, responding to accusations Ireland's gameplan is limited.
Garry Ringrose injured his hamstring in the loss in Dublin, so Farrell and Bundee Aki will make up the center pairing. Joe Schmidt said. "It's a pretty exciting opportunity to give Chris Farrell the chance to play against Scotland". It's a knock on top of a knock.
Schmidt, asked if Kearney would have been included at full-back even if Henshaw had been fit, replied: "Probably once Garry Ringrose was ruled out it was going to be trying to keep a little continuity as best we can and get as cohesive as we can in a short space of time".
"That hurt for sure and there weren't too many guys who slept well on Saturday night".
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