Fanned by high winds and fueled by low humidity and dry vegetation, the fires spread rapidly Thursday and overnight into Friday.
More than 75,000 homes were already under evacuation order in Ventura and Los Angeles counties due to the Woolsey Fire, reported at 3:30 a.m.at 8,000 acres with 0 percent containment, before it had jumped Highway 101.
That county is also facing danger from a second fire, the Hill Fire, which sparked Thursday very near the location of the mass shooting in Thousand Oaks where 12 were killed.
Melissa Etheridge was also forced to evacuate, and tweeted that she was safe in Santa Monica.
Rescuers used a bulldozer to push abandoned cars out of the way in order to reach a hospital and evacuate patients as the fire engulfed the building, Butte County Supervisor Doug Teeter said.
That fire - which ignited in Woolsey Canyon east of Simi Valley on Thursday - was burning toward Malibu on Friday.
"Imminent threat!" the department said in its warning.
The fire was driven by heavy winds last night. She had lived there since 2015, with the pad being prominently featured on her reality TV show. She and her husband eventually were able to drive away safely.
Caitlyn Jenner's Malibu home has unfortunately burned down in the horrific Woolsey fire raging through Southern California. A brush fire that was first reported at 2:00pm on Thursday afternoon, it's quickly grown in size as well.
Desperate residents fled their homes armed with pets and children to escape the burning flames. The Hill Fire is over 10,000 acres and the Woolsey Fire is 2,000 acres.
Early Friday morning, the wildfire jumped the 101 in Ventura County into Agoura Hills, closing a 4-mile stretch of the highway.
Santa Barbara County fire agencies sent strike teams to help fight the Ventura County fires and local law enforcement agencies sent personnel south to help evacuate residents and staff road closures, sheriff's spokeswoman Kelly Hoover said Friday.
Residents posted on social media to share their views of the flames almost consuming the hillside in the Newbury Park area of western Thousand Oaks.
While no homes or businesses have been lost because of the fast-moving fire, a number of RVs and outbuildings have been burned and a firefighter suffered a minor injury, authorities said.
Fire crews Thursday morning were dealing with 40 miles per hour wind gusts. The north and southbound lanes of the 101 freeway near Santa Rosa Road.
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