Roger Federer, who had already arrived late to the party in Paris, received another day off and a walk-over into the third round, as his would be opponent, Milos Raonic, announced his withdrawal from the Paris Masters 1000, citing an elbow injury.
Raonic injured himself during a three-set win against Jo-Wilfried Tsonga on Tuesday.
Spanish world number one Nadal and Serbian number two Djokovic - who are also in Paris for the Masters - said earlier in the week that they are reconsidering whether to play at King Abdullah Sports City in Jeddah just before Christmas. But the outcome proved to be double disappointment as both matches were cancelled and Nadal's participation at the upcoming Nitto ATP Finals thrown into doubt.
"I can not answer. I just go day by day", the 17-time Grand Slam champion said. He then skipped the Asia swing to recover, missing tournaments in Beijing and Shanghai.
"I feel like it would be better for me to play matches rather than practice" Federer said.
Djokovic issued a similar message, saying: "Of course I'm aware of what's happening and it's sad".
"It's been a hard year for me in terms of injuries, and so I'd prefer to avoid doing anything drastic", he added. "Something that I was not able to do this year, playing only nine events and retiring in two".
Nadal's withdrawal shortly before his match against fellow Spaniard Fernando Verdasco means Djokovic will overtake him when the new ATP rankings are published on Monday.
Sock and fourth-seeded Alexander Zverev reached round three in straight sets.
He will meet seventh seed Kevin Anderson or Georgian Nikoloz Basilashvili in the next round.
Gilles Simon was the only one of six Frenchmen to advance on Tuesday, defeating compatriot Lucas Pouille 6-3, 6-4, with Pierre-Hugues Herbert and qualifier Benoit Paire losing to Mikhail Kukushkin and Marton Fucsovics respectively.
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