It will be tough because they are must-win games.
Tottenham Hotspur suffered a defeat in their latest Champions League clash which proved to be an enthralling game at Wembley. If you watch the first half again, how many chances did he have? In the second half.
Barca set their stall out to end Real's European reign before a ball was even kicked this season with Messi in his first statement as new club captain after the exit of Andres Iniesta promising to "bring this attractive cup back home to the Camp Nou".
Tottenham are in danger of crashing out at the group stage for the second time in three years.
Spurs are still without a point in their Champions League group, having lost both of their matches so far against Inter Milan and Barcelona.
They head to PSV Eindhoven for their next European fixture on October 24 knowing a win is essential as they already trail Barca and Inter by six points. Yet, Spurs had chances and took two of them, and they showed real desire to try and drag themselves back into the game.
Lamela's deflected strike wrongfooted Ter Stegen and ensured a fantastic finale but, with Spurs committing men forward, Alba seized on a loose pass to set up Messi to sweep home his second.
Another poor decision from the French World Cup victor gave his side a mountain to climb as he raced from his goal and got caught in no man's land when Jordi Alba teed up Coutinho for the opener.
It was a bad mistake by Lloris in the French World Cup winner's first appearance since August after a torrid period marred by a thigh injury and his arrest for drink-driving.
Once again the creation and execution were breath-taking.
And, in case you are wondering, Messi has scored 562 goals in 647 games for Barcelona, with 105 in the Champions League.
Instead of being 4-0 down, however, Tottenham striker Kane halved the deficit in the 52nd minute with a clinical finish.
Barcelona were vulnerable so they said, but on a pitch scarred from hosting British heavyweight champion Anthony Joshua's fight against Alexander Povetkin they took only two minutes to catch Spurs in the solar plexus. Messi had the flawless response in the 56th minute when he cantered onto Alba's pass and side-footed past Lloris.
There was no let-up and after Kane worked hard to win the ball, Lamela gave Spurs another lifeline when his 66th-minute shot flicked off Clement Lenglet and past Ter Stegen.
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