Forecasters said "catastrophic" freshwater flooding was expected along waterways far from the coast of North and SC.
Earlier Friday, the Wilmington Police said they were responding to this incident.
It is expected to move across parts of south-eastern North Carolina and eastern SC on Friday and Saturday, then head north over the western Carolinas and central Appalachian Mountains early next week, the NHC said. "It's an uninvited brute who doesn't want to leave".
At least 150 people were waiting to be rescued in New Bern, N.C., officials tweeted Thursday evening.
More than 700,000 people were left without power and millions more were warned by the governor of North Carolina that they were facing "an extremely risky situation".
Coastal streets flowed with ocean water, and more than 460,000 homes and businesses were without power, mostly in North Carolina, according to poweroutage.us, which tracks the nation's electrical grid. As of Friday morning, Atlantic Beach, a town on the state's Outer Banks barrier islands, already had received 30 inches (76 cm) of rain, the U.S. Geological Service said.
A new 5-minute video from the space station shows Florence coming ashore in the US for the first time.
Hurricane Florence was downgraded to a Category 1 storm overnight.
Government weather satellites captured this image of Hurricane Florence shortly after its landfall September 14, 2018. Parts of North Carolina had seen storm surges - the bulge of seawater pushed ashore by the hurricane - as high as 3 metres, he said.
"It can not be emphasized enough that the most serious hazard associated with slow-moving Florence is extremely heavy rainfall, which will cause disastrous flooding that will be spreading inland", forecasters said, reports CBS News.
A North Carolina city says about 70 people have been rescued from a hotel whose structural integrity is being threatened by Hurricane Florence.
Florence, which is now a slow-moving Category 2 storm, is expected to linger over the Carolinas before turning north and sliding into western Virginia.
But it's not only North Carolinians who live along the coast who are being impacted by severe flooding. But once New Bern TV news station WCTI evacuated its newsroom Thursday night because of flooding and people began to lose power, the seriousness of the situation began dawning on folks, she said.
Duke has said it could take several weeks to fully restore power in areas that are inaccessible due to flooding. Fortunately for House, he says this storm should not be a devastating event for the beach town in terms of loss of life.
More than 12,000 people were in shelters in North Carolina and 400 in Virginia, where the forecast was less dire.
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