He has a flawless straight-sets record, and comes into this match against last year's US Open semi-finalist Kevin Anderson in the knowledge that the South African has never won a set against him in four matches.
The eighth seed Anderson did not look like causing a shock when he lost the first set 6-2 against the eight-time Wimbledon champion on Court No 1.
Federer was appearing at Wimbledon for the 20th time and 15 years after he first won the title, there were inevitably questions about whether the father of four had played his last match at his favourite tournament.
The three-time Wimbledon champion was broken in the opening game of the fourth set, but won the next four games and broke again to clinch victory.
Djokovic has got his wish as he will take on the world number 24 Kei Nishikori on Centre Court, while Federer will take on Anderson on court number one. "I played only once in first four matches on Centre Court".
"I feel like a lot of aspects of my game can give him a lot of trouble", said Anderson, the first South African man in the Wimbledon quarter-finals since Wayne Ferreira in 1994.
If he ever decides to stop playing tennis, Roger Federer may have a future in another sport.
South Africa's Kevin Andersonreacts during his quarter final match against Switzerland's Roger Federer.
"Well, it's going to happen anyway, if I'm going in the final or not, the Wimbledon final will take place, and so will the World Cup final", Federer said in a seemingly tongue-in-cheek response.
There was little sign of the drama which unfolded when Federer raced through the first set in 26 minutes. Anderson and Federer are knotted at 3-3 in the final set. Federer's forehand was inaccurate much of the day and he seemed bothered by Anderson's power.
Roger Federer's Wimbledon title defence is over following a dramatic five-set quarterfinal loss to an inspired Kevin Anderson on Wednesday (Thursday NZ Time). I think that's not fair.
"I think I had my chances, so it's disappointing".
Anderson then served it out, ending things with a 128 miles per hour service victor, and raised both arms overhead.
"Sure, it's disappointing losing the next two sets after winning the first two and having match points".
Federer eventually cracked at 11-11, double-faulting to hand Anderson a break point which he converted when the defending champion hit a weary-looking forehand halfway up the net.
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