Brosnahan's performance as Midge Maisel in "The Marvelous Mrs. Maisel" charmed members of the Hollywood Foreign Press Assn., with the first season of the series debuting on Amazon on November 29. This is the third time Amazon has won in this category: In 2016, Mozart in the Jungle won, and in 2015, Transparent took home the hardware.
Series creator Amy Sherman-Palladino accepted the award, briefly thanking the cast and crew.
By the end of the show's second hour, the Golden Globes ceremony had revealed this year's winners for Best Comedy or Musical Series and Best Drama Series.
And Sherman-Palladino ended her speech in only the way she could: "Is there cheese backstage?"
Brosnahan stars as Miriam "Midge" Maisel, a 1958 New York City woman who has everything she's ever wanted-the ideal husband, two kids and an elegant Upper West Side apartment. The series also stars Alex Borstein, Tony Shalhoub, Michael Zegen, and Marin Hinkle.
The Marvelous Mrs. Maisel beat out ABC's black-ish, Netflix's Master of None, Showtime's SMILF, and NBC's Will & Grace. The series has been renewed for two-season order by Amazon.
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