The Sixers (17-19) are 2-7 in games he has missed this season, though they beat the Denver Nuggets without him Saturday night.
Coach Brett Brown said before the game that Embiid was not likely to play.
Simmons, who played almost 34 minutes, made 8 of 18 attempts, and hit 10 of 15 free throws to clock 26 points, along with 5 rebounds, 4 assists, 3 steals and 1 block (box score). The Philadelphia 76ers are averaging 108.3 points on 46.1 percent shooting and allowing 108.8 points on 43.9 percent shooting.
But the 76ers rallied and rookie Simmons, who also contributed five rebounds, four assists and three steals, helped secure the result with a clever cut and dunk 21 seconds from full-time for the match-winning margin.
There are no betting lines established for this game due to Embiid's status as doubtful and because Leonard is unlikely to play on back-to-back nights. The Philadelphia 76ers have lost their last five home games. The Spurs are 5-12 ATS in the last 17 meetings in Philadelphia, 1-4 ATS in the last 5 meetings and the underdog is 4-1 ATS in the last 5 meetings.
Mills knocked down a deep 3-pointer for a 101-100 San Antonio advantage with 2:46 remaining, its first lead since 4-2.
A backcourt of Mills and Ginobili could be serviceable offensively without sacrificing much defensively if Anderson matches up against Simmons. Coming back with a winning record from a long road trip is another step in the right direction for this team's maturity.
Ben Simmons scored 26 points, Joel Embiid added 21 points and 11 rebounds, and JJ Redick had 20 points as the Philadelphia 76ers defeated the San Antonio Spurs, 112-106, Wednesday night at the Wells Fargo Center. Simmons had 19 points and nine assists to lead the Sixers to their fourth straight win, which moved them back to.500. Tip-off time is 7 pm EST.
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