Analysts had warned that the sacking would spark repercussions beyond Mugabe's control.
With Emmerson Mnangagwa now out of the way, President Mugabe's wife Grace, is now considered as the favourite to succeed her husband.
Mnangagwa - whose nickname is the "Crocodile" - defiantly told Mugabe that the party was "not personal property for you and your wife to do as you please".
Among the big wigs alleged to be loyal to the former vice president and facing the axe are state security minister Kembo Mohadi, cyber security mister Patrick Chinamasa and Environment minister Oppah Muchinguri.
Grace, now poised to become a vice president, did not fight in the liberation war. KGIV is the most fortified and biggest military barracks in the country and, save for the absence of generals from the Central Intelligence Organisation, Police and Correctional Services, Chiwenga had his ducks in a row and literally threw the gauntlet at Mugabe from the comfort of his citadel of power. Mr. Mugabe's party regained full control in 2013 elections that were widely seen as rigged.
Chiwenga urged unfettered participation at the party's December special congress to choose new leaders.
Chiwenga charged the ruling ZANU-PF party had been infiltrated by people who were seeking to destroy it from within. Chiwenga, in belligerent style demanded that "counter revolutionaries" - a euphemism for Moyo and his G40 acolytes - be expelled from Zanu PF.
Mnangagwa was subsequently fired from the party and has since left the country.
OVER 30 generals from the Zimbabwe Defence Forces packed the fortified KGIV army barracks in Harare as their boss issued a rare rebuke to President Robert Mugabe, leaving the country on the cusp of a coup, NewZimbabwe.com reported.
Among other security threats emanating from the goings-on Zanu-PF were "reckless utterances" by some politicians denigrating the military, which he said were causing despondency among its members, he said.
"It is with humility and a heavy heart that we come before you to pronounce the indisputable reality that there is instability in Zanu-PF today and as a result anxiety in the country at large", he said.
Zimbabwe in 2009 abandoned its own currency in favour of the USA dollar due to hyperinflation.
The bond notes themselves are running short, forcing banks to ration cash withdrawals.
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